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Medicine Overview of Folison 5mg Tablet
Indication
Anemia, Nutritional supplement, Folic acid deficiency, Megaloblastic anemia, Neural tube defect
Administration
May be taken with or without food.
Adult Dose
Oral Folate-deficient megaloblastic anaemia Adult: 5 mg daily for 4 mth, up to 15 mg daily in malabsorption states. Continued dosing at 5 mg every 1-7 days may be needed in chronic haemolytic states, depending on the diet and rate of haemolysis. Prophylaxis of megaloblastic anaemia in pregnancy Adult: 0.2-0.5 mg daily. Prophylaxis of neural tube defect in pregnancy Adult: 4 or 5 mg daily starting before pregnancy and continued through the 1st trimester. As supplement for women of child-bearing potential Adult: 0.4 mg daily.
Child Dose
Folic Acid Deficiency Infants: 15 mcg/kg/day or 50 mcg/day 1-10 years: 1 mg/day initially, then 0.1-0.4 mg/day
Contraindication
This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Folic Acid is contraindicated in untreated cobalamine deficiency.
Mode of Action
Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy.
Precaution
Treatment resistance may occur in patients with depressed haematopoiesis, alcoholism, deficiencies of other vitamins. Neonates. Lactation: Drug enters breast milk; safe for nursing
Side Effect
Bronchospasm,Erythema,Malaise,Pruritus,Rash,Slight flushing
Pregnancy Category Note
Pregnancy category: A Lactation: Drug enters breast milk; safe for nursing
Interaction
Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations.
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